KADEREIT, DIETER,SCHAEFER, MATTHIAS,HACHTEL, STEPHANIE,DIETRICH, AXEL,HUEBSCHLE, THOMAS,GILLE, ANDREAS,HISS, KATRIN
申请号：
ES11700098
公开号：
ES2453956T3
申请日:
2011.01.12
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound of the formula I, in any of its stereoisomeric forms, or a mixture of stereoisomeric forms in any relationship, or a physiologically acceptable salt thereof, or a physiologically acceptable solvate of any of them, ** Formula ** in which A you choose between NH, O and S； X is chosen from alkanediyl (C1-C6), alkenodiyl (C2-C6), alkynediyl (C2-C6), cycloalkanediyl (C3-C7) and alkanediyl (C1-C6) -oxy, all of which are optionally substituted with one or more same or different substituents chosen from fluorine and hydroxy, where the oxygen atom of the alkanediyl (C1-C6) -oxy group is attached to the group R2； R1 is chosen from (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C3-C7) cycloalkyl-CtH2t- and Het-CtH2t-, where t is chosen from 0, 1, 2 and 3； R2 is chosen from phenylene and a divalent moiety of an aromatic monocyclic heterocycle of 5 members to 6 members, comprising 1, 2 or 3 heteroatoms in the same or different ring chosen from N, O and S, where one of the nitrogen atoms the ring can carry a hydrogen atom or an R21 substituent, and where the phenylene and the divalent moiety of an aromatic heterocycle are optionally substituted on one or more carbon atoms of the ring with the same or different R22 substituents； R3 is chosen from (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C3-C7) cycloalkyl- and Het-CvH2v-, where u and v are chosen between 1 and 2, or R3 20 is a residue of a monocyclic or bicyclic ring, from 3 members to 10 members, saturated or unsaturated, comprising 0, 1, 2, 3 or 4 heteroatoms equal or different in the ring chosen from N, O and S, where one or two of the ring's nitrogen atoms can carry a hydrogen atom or a (C1-C4) alkyl substituent and one or two of the ring's sulfur atoms can carry one or two oxo groups, and where the rest of a ring is optionally substituted on one or more ring carbon atoms with the same or different R31 substituents, provided that R3 cannot be (C1-C6) alkyl - if a is S； R4 is chosen from hydrogen, (C1-C4) al
