DRESCHER, KARLA,HAUPT, ANDREAS,UNGER, LILIANE,TURNER, SEAN,BRAJE, WILFRIED,GRANDEL, ROLAND
申请号：
ES05795920
公开号：
ES2380565T3
申请日:
2005.10.14
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Aminoethyl aromatic compound of formula I in which Ar is a phenyl or an aromatic heteroaromatic radical linked to C of 5 or 6 members, in which Ar can carry 1 Ra radical and in which Ar can also carry 1 or 2 Rb radicals； Ra is selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, fluorinated C2-C6 alkenyl, C3-C6 cycloalkyl, C1-C6 alkoxy, fluorinated C1-C6 alkyl, fluorinated C3-C6 cycloalkyl, C1-C6 alkoxy fluorinated, hydroxy C1-C6 alkyl, C1-C6 alkoxy-C1-C4 alkyl, hydroxy C1-C6 alkoxy, C1-C6 alkoxy-C1-C4 alkoxy, COOH, NR4R5, CH2NR4R5, ONR4R510, NHC (O) NR4R5, C (O) NR4R5, SO2NR4R5, C1-C6 alkylcarbonyl, fluorinated C1-C6 alkylcarbonyl, C1-C6 alkylcarbonylamino, fluorinated C1-C6 alkylcarbonylamino, C1-C6 alkylcarbonyloxy, C1-C6 alkoxycarbonyl, C1-C6alkylcarbonyl C6 fluorinated, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, fluorinated C1-C6 alkylsulfinyl, fluorinated C1-C6 alkylsulfonyl, phenylsulfonyl, phenyl, phenoxy, benzyloxy and a 3 to 7 membered heterocyclic radical, in which the last five radicals mentioned they can carry 1, 2, 3 or 4 radicals selected from halogen, cyano, OH, oxo, CN and the radicals Ra, Rb se s independently selects halogen, cyano, nitro, OH, methyl, methoxy, fluoromethyl, difluoromethyl, trifluoromethyl, fluoromethoxy, difluoromethoxy and trifluoromethoxy, the radical Ra and an Rb radical, if present and attached to two carbon atoms of Adjacent phenyl may form a 5- or 6-membered heterocyclic or carbocyclic ring that condenses with the phenyl ring and is unsubstituted or that may carry 1, 2 or 3 radicals selected from halogen, NO2, NH2, OH, CN, alkyl C1-C6, C3-C6 cycloalkyl, C1-C6 alkoxy, fluorinated C1-C6 alkyl, fluorinated C3-C6 cycloalkyl, fluorinated C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C4 alkoxy-C2-C4 alkyl, hydroxyalkoxy C1- C6, C1-C4 alkoxy-C2-C4 alkoxy, C1-C6 alkylcarbonyl, C1-C6 alkylamino, C1-C6 dialkylamino, C1-C6 alkylaminocarbonyl, C1-C6 dialkylaminocarbonyl, fluorinated C1-C6 alkylcarbonyl, C1-C6 alkylcarbonylamino -C6 f
