Aromatic compounds substituted with arylsulfonylmethyl or arylsulfonamide suitable for treating disorders that respond to dopamine D3 receptor modulation
DRESCHER, KARLA,HAUPT, ANDREAS,UNGER, LILIANE,TURNER, SEAN COLM,BRAJE, WILFRIED,GRANDEL, ROLAND,HENRY, CHRISTOPHE
申请号：
ES12150319
公开号：
ES2529720T3
申请日:
2005.10.14
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
An aromatic compound of the formula I ** Formula ** where Ar is a phenyl or an aromatic heteroaromatic radical linked with C of 5 or 6 members, where Ar can carry 1 Ra radical and where Ar can carry 1 or 2 additional Rb radicals； Ra is selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, fluorinated C2-C6 alkenyl, C3-C6 cycloalkyl, C1-C6 alkoxy, fluorinated C1-C6 alkyl, C3- cycloalkyl C6 fluorinated, C1-C6 alkoxy fluorinated, C1-C6 hydroxyalkyl, C1-C6 alkoxy-C1-C4 alkyl, C1-C6 hydroxyalkoxy, C1-C6 alkoxy-C1-C4 alkoxy, COOH, NR4R5, CH2NR4R5, ONR4R5, NHC (O) NR4R5, C (O) NR4R5, SO2NR4R5, C1-C6 alkylcarbonyl, fluorinated C1-C6 alkylcarbonyl, C1-C6 alkylcarbonylamino, fluorinated C1-C6 alkylcarbonylamino, C1-C6 alkylcarbonyl, C1-C6 alkylcarbonyl fluorinated C1-C6 alkylcarbonyloxy, C1-C6 alkoxycarbonyl, C1-C6 alkylthio, fluorinated C1-C6 alkylthio, C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl, fluorinated C1-C6 alkylsulfinyl, C1-C6 alkylsulfonyl fluorinated, phenylsulfonyl, phenyl, phenoxy, benzyloxy and a 3- to 7-membered heterocyclic radical, where the last five mentioned radicals can carry 1, 2, 3 or 4 selected radicals of halogen, cyano, OH, oxo, CN, and the radicals Ra, Rb is, independently from each other, selected from halogen, cyano, nitro, OH, methyl, methoxy, fluoromethyl, difluoromethyl, trifluoromethyl, fluoromethoxy, difluoromethoxy and trifluoromethoxy, Ra radical and an Rb radical, if present and attached to two adjacent phenyl carbon atoms, can form a 5- or 6-membered heterocyclic or carbocyclic ring that is fused to the phenyl ring and which is unsubstituted or can carry 1, 2 or 3 radicals selected from halogen, NO2, NH2, OH, CN, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, fluorinated C1-C6 alkyl, fluorinated C3-C6 cycloalkyl, alkoxy C1-C6 fluorinated, hydroxyalkyl of C1-C6, alkoxy of C1-C4-alkyl of C2-C4, hydroxyalkoxy of C1-C6, alkoxy of C1-C4-alkoxy of C2-C4, alkylcarbonyl of C1-C6, alkylamino of C1 -C6, C1-C6 di-alkylamino, C1-C6 alkylamino
