KADEREIT, DIETER,SCHAEFER, MATTHIAS,HACHTEL, STEPHANIE,DIETRICH, AXEL,HUEBSCHLE, THOMAS,GILLE, ANDREAS,HISS, KATRIN
申请号：
ES11700136
公开号：
ES2449705T3
申请日:
2011.01.12
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound of formula I, in any of its stereoisomeric forms, or a mixture of stereoisomeric forms in any proportion, or its physiologically acceptable salt, or a physiologically acceptable solvate of any of these, ** Formula ** in which A is selected from NH, O and S； X is selected from alkanyl (C1-C6), alkenyl (C2-C6), alkyldiyl (C2-C6), cycloalkandiyl (C3-C7) and alkanoyloxy (C1-C6), all of which are optionally substituted with one or more substituents same or different selected from fluorine and hydroxy, in which the oxygen atom of the alkylethyloxy (C1-C6) group is attached to the group R2； Y represents a monocyclic or bicyclic heterocycle, saturated or partially unsaturated, of 4 members to 7 members which, in addition to the nitrogen atom of the ring shown in formula I, comprises 0, 1, 2 or 3 heteroatoms of the same or different ring selected from N, O and S, in which one or two of the additional ring nitrogen atoms may carry a hydrogen atom or a (C1-C4) alkyl substituent, and one of the ring sulfur atoms may carry one or two oxo groups, and wherein the heterocycle is optionally substituted at one or more ring carbon atoms with the same or different alkyl (C1-C4) substituents； R1 is selected from alkyl (C1-C6), alkenyl (C2-C6), alkynyl (C2-C6), cycloalkyl (C3-C7) -CtH2t- and Het-CtH2t-, in which t is selected from 0.1 , 2 and 3； R2 is selected from phenylene and a divalent moiety of a 5-membered or 6-membered monocyclic aromatic heterocycle, comprising 1, 2 or 3 same or different ring heteroatoms selected from N, O and S, in which one of the atoms of the ring nitrogen may carry a hydrogen atom or an R21 substituent, and in which the phenylene and the divalent moiety of an aromatic heterocycle are optionally substituted on one or more carbon atoms of the ring with the same or different R22 substituents； R3 is selected from alkyl (C1-C6), alkenyl (C2-C6), alkynyl (C2-C6), cycloalkyl (C3-C7) -CuH2u- and Het-CvH2v-, in which uyv are selected from 1 and 2 , or R3 rep
