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Tricyclic pyridyl vinyl pyrroles as inhibitors of PAR1
专利权人:
SANOFI
发明人:
SCHOENAFINGER, KARL,STEINHAGEN, HENNING,SCHEIPER, BODO,HEINELT, UWE,WEHNER, VOLKMAR,HERRMANN, MATTHIAS
申请号:
ES11715496
公开号:
ES2532902T3
申请日:
2011.04.14
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compound of the formula I ** Formula ** and / or all stereoisomeric or tautomeric forms of the compound of the formula I and / or mixtures of these forms in any proportion, and / or a physiologically acceptable salt of the compound of the formula I, wherein R1 and R2 are the same or different and independently represent each other, hydrogen, (C1-C6) alkyl, -O-(C1-C6) alkyl, aryl, halogen or heteroaryl, where alkyl, aryl and Hetaryl are in each case unsubstituted or are substituted once, twice or three times, independently of each other, with F, Cl, Br, CN, -C1-C4 alkyl, -O-C1-alkyl C4), -NH-(C1-C4) alkyl, -N ((C1-C4) alkyl) 2, -NH2, -OH, -O-CF3, -S-CF3 or -CF3, or R1 and R2 form , together with the ring atoms to which they are respectively attached, a 5-membered to 6-membered ring, wherein the ring is composed only of carbon atoms or 1, 2 or 3 of these atoms are replaced by atoms of N , of O or S, where the ring is unsubstituted or is substituted once, twice or three times, independently of each other, with F, Cl, Br, CN, -C1-C4 alkyl, -O-C1-C4 alkyl, -NH-(C1-C4) alkyl, -N ((C1-C4) alkyl) 2, -NH2, -OH, -O-CF3, -S-CF3 or -CF3; R3 and R4 form, together with the ring atoms to which they are respectively attached, a saturated or unsaturated ring of 5 members to 7 members, wherein the ring is composed only of carbon atoms or 1 or 2 of these atoms are replaced by O, S, SO, SO2 or N-R5, where the ring is unsubstituted or is substituted once, twice or three times, independently of each other, with F, Cl, -OH, -NH -R7, -C1-C4 alkyl, -O-C1-C4 alkyl, -C (O) -O-C1-C4 alkyl, aryl or hetaryl; X represents N-R6 or O; Y represents C (O), CH2, CH-CH3 or C (CH3) 2; R5 represents hydrogen, -C (O) -C1-C4 alkyl, -C (O) -O-C1-C4 alkyl, -C1-C6 alkyl, -C2-C4 alkyl -O- (C1-C4) alkyl, -C (C2-C4) alkyl -OH, aryl or heteroaryl, R7 represents hydrogen, -C (O) -C1-C4 alkyl, -C (O) -O-C1-alkyl C4), - (C1-C6) alkyl, - (C2-C4) alkyl - O (C1-C4) alkyl, - (C2-C4) alkyl -OH, aryl or hetaryl; R6 repres
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