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The indolizina derivatives as inhibitors of the Kinases fosfoinositido - 3
专利权人:
CHIESI FARMACEUTICI S.P.A.
发明人:
MICHELE RETINI,MATILDE GUALA,ANNA MARIA CAPELLI,ALESSANDRO ACCETTA,MATTEO BIAGETTI
申请号:
ARP150101923
公开号:
AR100879A1
申请日:
2015.06.16
申请国别(地区):
AR
年份:
2016
代理人:
摘要:
Claim 1: wherein is a compound of formula (1) where x u00b9, X, X and x u2074 CH groups are all or at least one of x u00b9, X, X and x u2074 is a nitrogen Atom and the others are CH groups; each, when present, is selected from the group consisting of or u2075: -, - S R u2075, - Q - S (o) - nr u00b9 u2070r u00b9 u00b9 r u2077, halogen, alkyl, c u2081 u208b u2086, c u2081 u208b u2086 haloalquilo, c u2081 u208b u2086 hidroxialquilo, c u2081 u208b u2086 aminoalquilo,C u2083 u208b u2087 cycloalkyl, c u2082 u208b u2086 alquenilo, c u2085 u208b u2087 cicloalquenilo, c u2082 u208b u2086 alquinilo, c u2082 u208b u2086 hidroxialquinilo or a group selected from aryl, heteroaryl and c u2083 u208b u2086 heterocicloalquilo each of each of which in turn is optionally substituted by indep Watching with one or More groups are selected from Halogen, alkyl - Oh, c u2081 u208b u2086, c u2081 u208b u2086 haloalquilo, c u2081 u208b u2086 hidroxialquilo, c u2081 u208b u2086 aminoalquilo,C u2083 u208b u2087 cycloalkyl, c u2082 u208b u2086 alquenilo, c u2085 u208b u2087 cicloalquenilo, c u2082 u208b u2086 alquinilo, c u2082 u208b u2086 hidroxialquinilo; r u00b9 is selected from the group consisting of H, or u2076 sr u2076 -, -, - S (o) Q - r u2078, halogen - nr u00b9 u00b2r u00b9 u00b3, - CN, - C (o) nr u00b9 u00b2r u00b9 u00b3, - C (o) or u00b9 u2076, c u2081 u208b u2086 alkyl, c u2081 u208b u2086 Haloalquilo, c u2081 u208b u2086 hidroxialquilo, c u2081 u208b u2086 aminoalquilo, c u2083 u208b u2087 cycloalkyl, c u2082 u208b u2086 alquenilo, c u2085 u208b u2087 cicloalquenilo, c u2082 u208b u2086 alquinilo, c u2082 u208b u2086 hidroxialquinilo,Or a group selected from aryl, heteroaryl and c u2083 u208b u2086 heterocicloalquilo each of each of which in turn is optionally substituted with one or More groups independently selected from Halogen, nr u00b2 u00b2r u00b2 u00b3 (-, - ch u2082) u2099nr u00b2 u00b2r u00b2 u00b3, c u2081 u208b u2086 alkyl, c u2081 u208b u2086 alkoxyl, c u2081 u208b u
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