LI, BING,WANG, LE,SHEPPARD, GEORGE S.,SCHRIMPF, MICHAEL,PRATT, JOHN,MDANIEL, KEITH F.,LIU, DACHUN,HASVOLD, LISA A.,FIDANZE, STEVEN D.
申请号：
ARP170100968
公开号：
AR108207A1
申请日:
2017.04.17
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
Claim 1: wherein is a compound of formula (1) or a pharmaceutically acceptable Salt thereof, where r u00b9 cd u2082cd u2083 c u2081 u208b u2086 is Hydrogen, alkyl, cycloalkyl, c u2081 u208b u2086 haloalquilo, c u2083 u208b u2086,PHENYL or heteroaryl monocyclic of 5-6 members； where the c u2083 u208b u2086 cycloalkyl, monocyclic heteroaryl phenyl, and 5 - 6 members are optionally substituted in each case with 1, 2, 3,Or 4 groups r u02e3 selected independently； R u00b2 is g u00b2 u1d43, c u2081 u208b u2086 haloalquilo,Where the alkyl or alkyl c u2081 u208b u2086 c u2081 u208b u2086 is optionally substituted with a Substituent selected from the group consisting g u00b2 u1d47 and - Oh； g u00b2 u1d43 is phenyl or cycloalkyl c u2083 u208b u2086 monocyclic； where eachG u00b2 u1d43 is optionally substituted with 1, 2, 3, or 4 groups r u02e3 selected independently； g u00b2 u1d47 is optionally substituted phenyl 1, 2, 3,Or 4 groups r u02e3 selected independently； r u00b3 is c u2081 u208b u2086 haloalquilo, c u2081 u208b u2086 alkyl, cycloalkyl or c u2083 u208b u2086 monoclinic monoclinic is where the c u2083 u208b u2086 cycloalkyl optionally replaced with 12, 3, or 4 groups r u02e3 selected independently； or R u00b2 and r u00b3, together with the carbon Atom to which they are attached, are c u2083 u208b u2086 cycloalkyl monocyclic, c u2084 u208b u2086 cicloalquenilo monocyclic,Monocyclic heterocycle or 4-6 members； where the c u2083 u208b u2086 cycloalkyl monocyclic, c u2084 u208b u2086 cicloalquenilo monocyclic,The monocyclic heterocycle and 4 - 6 members are optionally substituted in each case with 1, 2, 3, or 4 groups r u02e3 is selected independently； r u2074 pyridinyl, phenylC u2083 u208b u2086 cycloalkyl monocyclic, or c u2084 u208b u2086 cicloalquenilo monocyclic； where each r u2074 is optionally substituted with 1, 2, 3,Or 4 groups r u02b8 selected independently； or r u2074 is formula (2)； r u2074 u1d43 and r u2074 u1d47 are independently c u2081 u208b u2086 Halogen,
