123 62�2�2223The present invention relates to a compound of formula (I) wherein R is hydrogen lower alkyl lower alkyl substituted by halogen benzyl C(0) lower alkyl C(0) CH lower alkoxy C(0) C cycloalkyl (CH) C(0) NR R (CH)S(0) lower alkyl or S(0) NR R o is 0 or 1 R R are independently from each other hydrogen or lower alkyl or may form together with the N atom to which they are attached a 5 or 6 membered heterocycloalkyl ring R is hydrogen or lower alkyl R is halogen lower alkoxy lower alkyl substituted by halogen or lower alkoxy substituted by halogen and may be the same or different in case n is 2 n is 1 or 2 Ar is phenyl optionally substituted by one or two substituents selected from lower alkyl halogen lower alkoxy lower alkyl substituted by hydroxy or cyano or is a five or six membered heteroaryl group selected from thiophenyl or pyridinyl which are optionally substituted by lower alkyl or halogen or to a pharmaceutically active acid addition salt. It has surprisingly been found that the compounds of formula I show a high affinity simultaneously to both the NK1 and the NK3 receptors (dual NK1/NK3 receptor antagonists) useful in the treatment of schizophrenia.
