This disclosure provides methods of using compositions comprising amino acid entities to reduce fat infiltration in muscle, particularly under conditions of muscle atrophy. The disclosure also provides methods for enhancing muscle function by reducing fat infiltration in the muscle comprising administering an effective amount of the compositions to a subject in need thereof.本發明提供一種使用包含胺基酸實體之組合物,尤其在肌肉萎縮之條件下,降低肌肉中之脂肪浸潤之方法。本發明亦提供藉由降低肌肉中之脂肪浸潤來增強肌肉功能之方法,其包括向有需要之個體投與有效量之組合物。