A method of treating HIV comprising intramuscular administration once every 4 weeks or longer of a combination of cabotegravir or a pharmaceutically acceptable salt thereof and rilpivirine or a pharmaceutically acceptable salt thereof.本發明揭示一種治療HIV的方法,包含每4週或更久一次肌肉內投與卡博拉韋(cabotegravir)或其醫藥上可接受之鹽以及利匹韋林(rilpivirine)或其醫藥上可接受之鹽的組合。