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Method for producing pitavastatin calcium
专利权人:
API CORPORATION
发明人:
Naoyuki Watanabe,Takanobu Iura,Hideki Oomiya,Masaki Nagahama
申请号:
US15749377
公开号:
US10676441B2
申请日:
2016.08.05
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Production of pitavastatin calcium safely on an industrial scale with a high yield and high selectivity at low cost. A method of producing pitavastatin calcium including step (i) for acetalizing a compound represented by the formula (1) to give a compound represented by the formula (3), step (ii) for reacting a compound represented by the formula (3) with an acid to give a compound represented by the formula (4), and step (iii) for hydrolyzing a compound represented by the formula (4) and reacting same with a calcium compound.
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