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AN INSULIN CONJUGATE USING AN IMMUNOGLOBULIN FRAGMENT
专利权人:
发明人:
申请号:
EP11763093.9
公开号:
EP2552474B1
申请日:
2011.04.04
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment.
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