SONG DAE HAE,SHIN JAE HEE,PARK YOUNG JIN,IM DAE SEONG,BAE SUNG MIN,KWON SE CHANG
申请号：
ZA201208189
公开号：
ZA201208189B
申请日:
2012.10.31
申请国别(地区):
ZA
年份:
2013
代理人:
摘要：
The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment.
