SONG DAE HAE,SHIN JAE HEE,PARK YOUNG JIN,IM DAE SEONG,BAE SUNG MIN,KWON SE CHANG
申请号：
MYPI 2012004365
公开号：
MY152304A
申请日:
2011.04.04
申请国别(地区):
MY
年份:
2014
代理人:
摘要：
THE PRESENT INVENTION RELATES TO AN INSULIN CONJUGATE HAVING IMPROVED IN VIVO DURATION AND STABILITY, WHICH IS PREPARED BY COVALENTLY LINKING INSULIN WITH AN IMMUNOGLOBULIN FC REGION VIA A NON-PEPTIDYL POLYMER, A LONG-ACTING FORMULATION COMPRISING THE SAME, AND A PREPARATION METHOD THEREOF. THE INSULIN CONJUGATE OF THE PRESENT INVENTION MAINTAINS IN VIVO ACTIVITY OF THE PEPTIDE AT A RELATIVELY HIGH LEVEL AND REMARKABLY INCREASES THE SERUM HALF-LIFE THEREOF, THEREBY GREATLY IMPROVING DRUG COMPLIANCE UPON INSULIN TREATMENT. (FIG. 1)
