Song, Dae Hae,Shin, Jae Hee,Park, Young Jin,Im, Dae Seong,Bae, Sung Min,Kwon, Se Chang
申请号：
AU2011233800
公开号：
AU2011233800A1
申请日:
2011.04.04
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment.
