Dae Hae Song,Jae Hee Hee Shin,Young Jin Park,Dae Seong Im,Sung Min Bae,Se Chang Kwon
申请号：
US15286871
公开号：
US09981017B2
申请日:
2016.10.06
申请国别(地区):
US
年份:
2018
代理人:
摘要：
An insulin conjugate having improved in vivo duration and stability is provided. The conjugate is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment.
