BROWN, JULIEN ALISTAIR,BROOKINGS, DANIEL CHRISTOPHER,HEER, JAG PAUL,JOHNSON, JAMES ANDREW,ZHU, ZHAONING
申请号：
CA3055863
公开号：
CA3055863A1
申请日:
2018.03.14
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
A series of substituted fused pentacyclic imidazopyridine and imidazopyridazine derivatives, and analogues thereof, being potent modulators of human TNFa activiy, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders； neurological and neurodegenerative disorders； pain and nociceptive disorders； cardiovascular disorders； metabolic disorders； ocular disorders； and oncological disorders.
