ALEXANDER, RIKKI PETER,BROWN, JULIEN ALISTAIR,DELIGNY, MICHAEL,HEER, JAG PAUL,JACKSON, VICTORIA ELIZABETH,JADOT, SOPHIE,KROEPLIEN, BORIS,MAC COSS, MALCOLM,SABNIS, YOGESH ANIL,SWINNEN, DOMINIQUE LOUIS
申请号：
CA2932057
公开号：
CA2932057A1
申请日:
2014.12.08
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
A series of substituted fused tricyclic imidazole derivatives, in particular dihydro- 1H-pyrano[4',3':4,5]imidazo[1,2-a]pyridine, 1,2,3,4-tetrahydroimidazo[1,2-a:5,4- c']dipyridine, dihydro-1H-pyrano[3',4':4,5]imidazo[1,2-a]pyridine and tetrahydro-6H- cyclohepta[4,5]imidazo[1,2-a]pyridine, and analogues thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders； neurological and neurodegenerative disorders； pain and nociceptive disorders； cardiovascular disorders； metabolic disorders； ocular disorders； and oncological disorders.
