ALEXANDER, RIKKI PETER,BRACE, GARETH NEIL,BROWN, JULIEN ALISTAIR,CALMIANO, MARK DANIEL,CHOVATIA, PRAFUL TULSHI,DELIGNY, MICHAEL,GALLIMORE, ELLEN OLIVIA,HEER, JAG PAUL,JACKSON, VICTORIA ELIZABETH,KROEP
申请号：
CA2931758
公开号：
CA2931758A1
申请日:
2014.12.08
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
A series of fused tricyclic imidazole derivatives, in particular dihydro-1H-cyclopenta[4,5]imidazo[1,2-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders； neurological and neurodegenerative disorders； pain and nociceptive disorders； cardiovascular disorders； metabolic disorders； ocular disorders； and oncological disorders.
