ALEXANDER, RIKKI PETER,CALMIANO, MARK DANIEL,DEFAYS, SABINE,DURIEU, VERONIQUE,DELIGNY, MICHAEL,HEER, JAG PAUL,JACKSON, VICTORIA ELIZABETH,KEYAERTS, JEAN,KROEPLIEN, BORIS,MAC COSS, MALCOLM,SABNIS, YOGE
申请号：
CA2932008
公开号：
CA2932008A1
申请日:
2014.12.08
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
A series of tricyclic benzimidazole derivatives, in particular dihydro-1H- imidazo [1,2-a]benzimidazo le, dihydro-1H-pyrrolo [1,2-a]benzimidazo le, dihydro-1H- pyrazino[1,2-a]benzimidazole, dihydro-1H-[1,4]oxazino[4,3-a]benzimidazole and dihydrothiazolo[3,4-a]benzimidazolem, and analogues thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders； neurological and neurodegenerative disorders； pain and nociceptive disorders； cardiovascular disorders； metabolic disorders； ocular disorders； and oncological disorders.
