Rikki Peter Alexander,Mark Daniel Calmiano,Sabine Defays,Veronique Durieu,Michael Deligny,Jag Paul Heer,Victoria Elizabeth Jackson,Jean Keyaerts,Boris Kroeplien,Malcolm Mac Coss,Yogesh Anil Sabnis,Mat
申请号：
US15102003
公开号：
US09932343B2
申请日:
2014.12.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A series of tricyclic benzimidazole derivatives, in particular dihydro-1H-imidazo [1,2-a]benzimidazole, dihydro-1H-pyrrolo [1,2-a]benzimidazole, dihydro-1H-pyrazino[1,2-a]benzimidazole, dihydro-1H-[1,4]oxazino[4,3-a]benzimidazole and dihydrothiazolo[3,4-a]benzimidazolem, and analogs thereof, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders； neurological and neurodegenerative disorders； pain and nociceptive disorders； cardiovascular disorders； metabolic disorders； ocular disorders； and oncological disorders.
