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α,β-unsaturated amide compound
专利权人:
KYOWA KIRIN CO.; LTD.
发明人:
Tomohiro Danjo,Katsuaki Fujiwara,Tomoyuki Nishikawa,Takahiro Nakajima,Nobumasa Otsubo,Toshihiro Seike
申请号:
US16065937
公开号:
US10787428B2
申请日:
2016.12.22
申请国别(地区):
US
年份:
2020
代理人:
摘要:
The present invention provides an α,β-unsaturated amide compound or a pharmaceutically acceptable salt or the like thereof having anticancer activity and the like represented by the following formula (I):[wherein, “A” represents optionally substituted heterocyclic diyl,R1 represents hydrogen atom or optionally substituted lower alkyl,R2 represents optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted aliphatic heterocyclic group or optionally substituted aromatic heterocyclic group,X represents —;O—;, —;S—;, —;SO2—;, —;NRX1—; (wherein, RX1 represents hydrogen atom or lower alkyl), —;CHRX2—; (wherein, RX2 represents hydrogen atom or hydroxy), —;CH═;CH—;, —;CO—; or —;NH—;CO—;, andn1 and n2 are the same or different, and each represents 0 or 1].
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