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Nuevos compuestos antibacterianos heterocíclicos
专利权人:
MICROBIOTIX; INC.
发明人:
ZHI, CHENGXIN,WRIGHT, GEORGE E.
申请号:
ES02763207
公开号:
ES2392819T3
申请日:
2002.06.17
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound of any of formulas (3), (4), (5), (6), (7) and (8) as follows: where the segment AB is any of the radicals formula (9), (10) and (11) below: wherein B is R2 segment and the segment a is the remaining portion of the formulas (9) - (11) X is N or a carbon ring with the substituent R1 substituted, wherein R1 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl and optionally substituted aryl R2 is a substituent with the bonding points indicated selected from the group consisting of: wherein Et is ethyl and wherein said substituent R2 is bonded to the remaining portion of the formulas (9) - (11) through one of the two connecting points indicated and is connected through the other point of attachment to C segment R3 is N or a carbon ring substituted with the substituent R8, wherein R8 is selected from the group consisting of H, optionally substituted aryl, alkyl, optionally substituted alkenyl, alkynyl, alkoxy, amino, alkylamino, cyano, nitro or halo or R1 and R8 join to form a carbocyclic or heterocyclic ring of 4-8 members, fused, optionally substituted, which is saturated, unsaturated, or aromatic, wherein the heterocyclic ring comprises 1-3 heteroatoms selected from the group It is consisting of S, N and O R4 is N or a carbon ring substituted with the substituent R9, wherein R9 is selected from the group consisting of H, optionally substituted aryl, optionally substituted alkyl, alkenyl, alkynyl, alkoxy, amino, alkylamino, cyano, nitro or halo or R2 and R9 are joined to form a fused, carbocyclic or heterocyclic ring of 4-8 membered optionally substituted, which is saturated, unsaturated or aromatic, wherein the heterocyclic ring comprises 1-3 heteroatoms selected from the group consisting of in S, N and O R5 is selected from the group consisting of H, halo, amino, alkylamino, and alkyl of 1-6 carbons and R6 is N or a carbon ring substituted with the substituent R7, wherein R7 is selected from the group consisting of H, halo and alky
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