LINK, JOHN O.,MOSSMAN, CRAIG J.,WOO, SOON H.,ZIPFEL, SHEILA M.
申请号：
ES04784332
公开号：
ES2534222T3
申请日:
2004.09.17
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of Formula (I): ** Formula ** wherein: R1 and R2 taken together with the carbon atom to which both R1 and R2 are attached, form (i) cycloalkylene optionally substituted with one or two independently selected Rb from alkyl, halo, alkylamino, dialkylamino, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroaralkyl, alkoxycarbonyl, or aryloxycarbonyl, (ii) heterocyclylalkylene optionally substituted with one to four Rc independently selected from alkyl, haloalkyl, hydroxy, alkoxyalkyl, alkoxyalkyloxyalkyl, aryloxyalkyl, heteroaryloxyalkyl, aminoalkyl, acyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl, cycloalkylalkyl, -S (O) n2R14, -alkylene-R (O) N -OR-R, O15-O-R15 COOR17, -CONR18R19, or - alkylene-CONR20R21 where n2 is 0-2 and R14-R17, R18 and R20 are independently hydrogen, alkyl, haloalkyl, aryl, aralkyl, heter oaryl, heteroaralkyl, cycloalkyl, cycloalkylalkyl, or heterocyclyl and R19 and R21 are independently hydrogen or alkyl wherein the aromatic or alicyclic ring in the groups linked to cycloalkylene or heterocyclylalkylene is optionally substituted with one, two, or three substituents independently selected from alkyl, haloalkyl, alkoxy, hydroxy, haloalkoxy, halo, carboxy, alkoxycarbonyl, amino, monosubstituted amino, disubstituted amino, or acyl； R3 is hydrogen； R5 is hydrogen； where cycloalkyl is a monovalent saturated or partially unsaturated monocyclic ring comprising from three to eight carbon atoms in the ring and cycloalkylene refers to a divalent saturated or partially unsaturated monocyclic ring containing from three to eight carbon atoms； and wherein R4 is ethylthiomethyl, ethylsulfinylmethyl, ethylsulfonylmethyl, isopropylthiomethyl, 2-methylthioethyl, 2-methylsulphinylethyl, 2- metisulfoniletilo, 2-metilpropilsulfonilmetilo, isobutilsulfanilmetilo, tert-butylthiomethyl, benzenesulfonylmethyl, 2-phenyl- sulfaniletilo, 2-phenylsulfonylethyl, naphth-2 -ilmetanosulfonilmetilo, biphenyl-2-il
