The invention provides novel pyrophosphate synthase inhibitors of formula (I), wherein R1 is a saturated or unsaturated: (C5-C20)alkyl chain that optionally comprises one or more aryl rings in the chain and that is optionally substituted with one or more halo, trifluoromethyl, -ORa, -P(=O)(ORa)2, or -NRbRc R2 is a saturated or unsaturated (C5-C20)alkyl chain that optionally comprises one or more aryl rings in the chain and that is optionally substituted with one or more halo, trifluoromethyl, -ORa, -P(=O)(ORa)2, or -NRbRc R2 each R3, R4, R5, and R6 is independently OH or (C1-C6)alkoxy each Ra is independently H, (C1-C6)alkyl, or aryl and .each Rb and Rc is independently H, (C1-C6)alkyl, or aryl or Rb and Rc together with the nitrogen to which they are attached form a pyrrolidino, piperidino, morpholino, or thiomorpholino ring wherein any aryl is optionally substituted with one or more (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)alkanoyl, (C1-C6)alkanoyloxy, (C1-C6)alkoxycarbonyl, halo, cyano, nitro, carboxy, trifluoromethyl, trifluoromethoxy, NRdRe, or S(O)2NRdRe, wherein each Rd and Re is independently H or (C1-C6)alkyl or a pharmaceutically acceptable salt or prodrug thereof. Also provided are compositions comprising such inhibitors and methods for their use.Linvention concerne de nouveaux inhibiteurs de la pyrophosphate synthase de la formule (1), des compositions renfermant lesdits inhibiteurs et leurs procédés dutilisation.
