A compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein: Q1 is aryl1, which is optionally substituted with one to five independent G1 substituents； R1 is alkyl, cycloalkyl, aryl, aralkyl or heterocyclyl, any of them is optionally substituted with one or more independent G11 substituents； G1 is halo, -OR2, or - (X1) n- (Y1) m-R4； G41 is halo, -CF3, -OCF3, -OR2, -NR2R3 (R3a) j1, -CONR2R3, NR2 (C = O) R3, -S (C = O) OR2, C0-10 alkyl or C1-10 alkoxy- C2-10 alkenyl, any of them is optionally substituted with one or more halo, -OR222, - NR222R333 (R333a) j1a, -C (O) R222 or S (O) j1aR222； C0-10 aryl-alkyl； or hetaryl-C0-10 alkyl； G11 is halo, -OR21, -NR21R31 (R3a1) j4, -C (O) R21, -CO2R21, -CONR21R31, C0-10 alkyl, C2-10 alkenyl, C1-10 alkoxy-C1-10 alkyl, C3 cycloalkyl 8 or heterocyclyl-C0-10 alkyl, any of them is optionally substituted with one or more -OR2221, -NR2221R3331 (R333a1) j4a, -CONR2221R3331 or NR2221 (C = O) R3331 independent； or aryl-C0-10 alkyl； R2, R3, R3a, R222, R333, R333a, R21, R31, R3a1, R2221, R3331 and R333a1 are each equal to C0-10 alkyl, C3-8 cycloalkyl, heterocyclyl-C0-10 alkyl, aryl-C0-alkyl 10 or heteroaryl-C0-10 alkyl； or in the case of NR2R3 (R3a) j1 or NR222R333 (R333a) j1a or -NR2221R3331 (R333a) j4a or R2 and R3 or R222 and R333 or R2221 and R3331 can be taken together with the nitrogen atom to which they are attached to form a saturated ring, unsaturated ring, heterocyclic saturated ring or 3-10 membered heterocyclic unsaturated ring, wherein said ring is optionally substituted with one or more G111 substituents； X1 and Y1 are each independently -O- or -CR5R6-； R5 and R6 are C0-10 alkyl； G111 is C0-10 alkyl or heterocyclyl-C0-10 alkyl, any of them is optionally substituted with one or more halo, -OR77 or -NR77R87 independent； or aryl-C0-10 alkyl； or hetaryl-C0-10 alkyl； R4 is aryl, heteroaryl, cycloalkyl or heterocyclyl, any of them is optionally substituted with one or more G41 substituents； R77 is each
