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抗腫瘤劑之效果增強劑
专利权人:
TAIHO PHARMACEUTICAL CO.; LTD.
发明人:
FUJITA, HIDENORI,藤田英宪,藤田英憲,KATO, MASANORI,加藤正德
申请号:
TW101150217
公开号:
TW201331182A
申请日:
2012.12.26
申请国别(地区):
TW
年份:
2013
代理人:
摘要:
An antitumor effect potentiator for other antitumor agents, which contains, as an active ingredient, an acylthiourea compound represented by general formula (I) or a pharmaceutically acceptable salt thereof. (In the formula, R1 represents a C1-6 alkyl group which may have a substituent, and the substituent is a hydroxyl group, a C3-10 cycloalkyl group, a C1-6 alkoxy group which may have a substituent, a C1-6 alkylamino group which may have a substituent, a C1-6 alkanoyl amino group, a C1-6 alkylsulfonyl group, a C6-14 aromatic hydrocarbon group which may have a substituent, a saturated or unsaturated heterocyclic group which may have a substituent, a C1-6 alkylamino carbonyl group which may have a substituent, or a saturated or unsaturated heterocyclic carbonyl group which may have a substituent; R2 represents a fluorine atom or a chlorine atom; and R3 represents a hydrogen atom, a fluorine atom or a chlorine atom.)本發明提供一種抗腫瘤劑效果增強劑,其係其他抗腫瘤劑之抗腫瘤效果增強劑,且以通式(I)所表示之醯基硫脲化合物或其藥學上所容許之鹽為有效成分:(式中,R1表示亦可具有取代基之C1-6烷基,作為該取代基,表示羥基、C3-10環烷基、亦可具有取代基之C1-6烷氧基、亦可具有取代基之C1-6烷基胺基、C1-6烷醯基胺基、C1-6烷基磺醯基、亦可具有取代基之C6-14芳香族烴基、亦可具有取代基之飽和或不飽和雜環基、亦可具有取代基之C1-6烷基胺基羰基、亦可具有取代基之飽和或不飽和雜環羰基中任一種,R2表示氟原子或氯原子,R3表示氫原子、氟原子、或氯原子),
来源网站:
中国工程科技知识中心
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