The present invention provides a compound represented by the general formula (I) or pharmacologically acceptable salts thereof,[in formula, R1 represents C1~C6 alkyl optionally substituted by 1~3 substituents selected from substituent group A(substituent group A: hydroxyl, halo, cyano, nitro, amino, carboxyl, C1~C3 alkyl etc.)； R2, R3 and R8 represent each independently, hydrogen atom or C1~C3 alkyl；R4, R5, R6, R7, R9 and R10 represent each independently, hydrogen atom etc.； R11 represents hydrogen atom etc.].The compound has the inhibition activity to TAFIa enzyme and is useful as a therapeutic agent for cardiac infarction, stenocardia, acute coronary syndrome, brain infarction, deep vein thrombosis, pulmonary embolism and the like.一種以下列通式(I)表示的化合物或其在藥理上可容許之鹽：[式中，R1表示可經選自取代基群A當中1~3個取代之C1~C6烷基等(取代基群A：羥基、鹵代基、氰基、硝基、胺基、羧基、C1~C3烷基等)，R2、R3及R8各自獨立而表示氫原子或C1~C3烷基，R4、R5、R6、R7、R9及R10各自獨立而表示氫原子等，R11表示氫原子等]，其具有TAFIa酵素抑制活性，且有用於作為心肌梗塞、心絞痛、急性冠狀動脈功能不全症候群、腦梗塞、深部靜脈血栓症、肺栓塞症等之治療藥。
