DEHMLOW, Henrietta,MARTIN, Rainer E.,MATTEI, Patrizio,OBST SANDER, Ulrike,RICHTER, Hans
申请号：
ES12784005
公开号：
ES2563157T3
申请日:
2012.11.12
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compounds of formula: ** Formula ** in which: R 1 is heteroaryl selected from the group consisting of pyridazine-4-yl, 3-oxo-2,3-dihydropyridazine-4-yl and 6- oxo-1, 6-dihydropyridazin-3-yl, said heteroaryl being unsubstituted or substituted with one, two or three groups independently selected from the group consisting of C1-7 alkyl, halogen, halogen-C1-7 alkyl, hydroxy, hydroxyalkyl C1- 7, C1-7 alkoxy and C1-7 alkoxy-C1-7 alkyl, R2 is selected from the group consisting of C1-7 alkyl, C3-7 cycloalkyl, C2-7 alkenyl, halogen-C1-7 alkyl, phenyl unsubstituted or phenyl substituted with one, two or three groups independently selected from the group consisting of C1-7 alkyl, halogen, halogen-C1-7 alkyl, halogen-C1-7 alkoxy and C1-7 alkylsulfonyl, and heteroaryl, said heteroaryl being unsubstituted or substituted with C1-7 alkyl or oxo, R3 and R7 are independently selected from each other from the group or consisting of hydrogen, halogen and C1-7 alkyl, and R4, R5 and R6 are independently selected from the group consisting of hydrogen, halogen, halogen C1-7 alkyl, cyano, cyano-C1-7 alkyl, C1 alkyl -7, C 1-7 alkenyl, C 1-7 alkynyl, C 1-7 alkoxy, C 1-7 alkoxy-C 1-7 alkyl, hydroxy, C 1-7 hydroxyalkyl, C 3-7 hydroxyalkenyl, C 3-7 hydroxyalkynyl, C 1-7 hydroxy -alkoxy, carboxyl, carboxy-C 1-7 alkyl, carboxy-C 3-7 alkenyl, carboxy-C 1-7 alkynyl, carboxy-C 1-7 alkoxy, tetrazolyl, C 1-7 alkoxycarbonyl, C 1-7 alkylsulfonyl, C 1-7 alkylsulfonyloxy 7, C1-7 alkyl sulfonylamino, C3-7 cycloalkyl sulfonylamino, aminosulfonyl, (C1-7 alkyl) - aminosulfonyl, di- (C1-7 alkyl) -aminosulfonyl, heterocyclylsulfonyl, C1-7 alkylamino, di- (C1 alkyl -7) -amino, C 1-7 alkoxy-C 1-7 alkylamino, C 1-7 alkoxy-C 1-7 alkylamino, C 1-7 alkoxy-halogen-C 1-7 alkylamino, C 1-7 hydroxyalkyl, C 1-7 alkylamino, an amino acid linked by the amino group of the amino acid, cic C3-7 lokylamino, in which C3-7 cycloalkyl is not substituted or substituted with hydroxy, C1-7 hydroxyalkyl or carboxyl, carboxyl-C1-7-amino
