Irvin Chen,Dong Sung An,Michelle L. Millington,Maureen P. Boyd,Geoffrey P. Symonds,Louis Randall Breton
申请号：
US13384206
公开号：
US20120201794A1
申请日:
2010.05.26
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides an expression vector for preventing or inhibiting HIV entry, fusion or replication in mammalian cells. In particular, the invention provides a recombinant retroviral vector that encodes an inhibitor of a HIV co-receptor, such as CCR5 or CXCR4, and a protein that inhibits HIV fusion to target cells and/or HIV replication. Pharmaceutical compositions comprising such constructs and methods of use thereof to prevent or treat HIV infection in a patient are also disclosed.
