Irvin CHEN,Dong Sung AN,Michelle MILLINGTON,Maureen BOYD,Geoffrey P. SYMONDS,Louis Randall BRETON
申请号：
US15150373
公开号：
US20160243169A1
申请日:
2016.05.09
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides an expression vector for preventing or inhibiting HIV entry, fusion or replication in mammalian cells. In particular, the invention provides a recombinant retroviral vector that encodes an inhibitor of a HIV co-receptor, such as CCR5 or CXCR4, and a protein that inhibits HIV fusion to target cells and/or HIV replication. Pharmaceutical compositions comprising such constructs and methods of use thereof to prevent or treat HIV infection in a patient are also disclosed.
