Chen, Irvin,An, Dong Sung,Millington, Michelle,Boyd, Maureen,Symonds, Geoffrey P.,Breton, Louis Randall
申请号：
AU2017254831
公开号：
AU2017254831A1
申请日:
2017.10.31
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
#$%^&*AU2017254831A120171116.pdf#####ABSTRACT The present invention provides an expression vector for preventing or inhibiting HIV entry, fusion or replication in mammalian cells. In particular, the invention provides a recombinant retroviral vector that encodes an inhibitor of a HIV co-receptor, such as CCR5 or CXCR4, and a protein that inhibits HIV fusion to target cells and/or HIV replication. Pharmaceutical compositions comprising such constructs and methods of use thereof to prevent or treat HIV infection in a patient are also disclosed.WO1 2011/008348 PCT/US2O1O/036247 1/2 W44 KiIE omom o It .. .. .. . ........ ,
