Breton, Louis Randall,Chen, Irvin,An, Dong Sung,SYMONDS, Geoffrey P.,Boyd, Maureen,Millington, Michelle L.
申请号：
DK15166660
公开号：
DK2949208T3
申请日:
2010.05.26
申请国别(地区):
DK
年份:
2018
代理人:
摘要：
The present invention provides an expression vector for preventing or inhibiting HlV entry, fusion or replication in mammalian cells. In particular, the invention provides a recombinant retroviral vector that encodes an inhibitor of a HlV co-receptor, such as CCR5 or CXCR4, and a protein that inhibits HIV fusion to target cells and/or HIV replication. Pharmaceutical compositions comprising such constructs and methods of use thereof to prevent or treat HIV infection in a patient are also disclosed.
