БЛЮ Джеффри Т. (US),КЭННОН Джейм (US),СМИТ Уилльям Дж. (US),ГРИН-ТЕКСЛЕР Эрин Дж. (US),ЗИГФРИД Бретт (US)
申请号：
RU2013131795/15
公开号：
RU2013131795A
申请日:
2011.12.05
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A composition comprising (i) pH-buffered saline with a pH in the range of 5,0 to 8,0, (ii) a poloxamer having a molecular weight ranging from 1,100 to 17,400 and (iii) one or more polysaccharide-protein conjugates .2. A composition according to claim 1, wherein the poloxamer has a molecular weight ranging from 7500 to 15000.3. A composition according to claim 1, wherein the poloxamer has a molecular weight ranging from 7500 to 10000.4. A composition according to claim 1, wherein the poloxamer is poloxamer 188 or poloxamer 237.5. A composition according to any one of claims 1-4, wherein the final concentration of the poloxamer in the composition is from 0.001% to 5% w / v of the kompozitsii.6. A composition according to any one of claims 1-4, wherein the final concentration of the poloxamer in the composition is from 0.025% to 1% w / v of the kompozitsii.7. A composition according to any one of claims 1-4, wherein the final concentration of Poloxamer 188 in the composition is from 0.05% to 1.0% w / v of the composition or the final concentration of Poloxamer 237 in the composition is from 0.1% to 1.0% w / v of the kompozitsii.8. A composition according to any one of claims 1-4, wherein the pH-buffered saline has a pH in the range from 5.2 to 8,0.9. A composition according to any one of claims 1-4, wherein the buffer is selected from the group consisting of Tris, phosphate, succinate, histidine, MES, MOPS, HEPES, acetate or tsitratnogo.10. A composition according to any one of claims 1-4, wherein the buffer is a histidine at a final concentration of 5 mM to 50 mM, or succinate at a final concentration of 1 mM to 20 mM.11. A composition according to any one of claims 1-4, wherein the salt solution is present in a concentration of from 20 nM to 170 nM.12. A composition according to any one of claims 1-4, wherein the protein is1. Композиция, содержащая (i) pH-забуференный солевой раствор с pH в диапазоне от 5,0 до 8,0, (ii) полоксамер с молекулярной массой в диапазоне
