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ВОДНЫЕ ГЕЛЕОБРАЗУЮЩИЕ КОМПОЗИЦИИ РАСТВОРИМЫХ АКТИВНЫХ ФАРМАЦЕВТИЧЕСКИХ ПЕПТИДОВ, ОБЕСПЕЧИВАЮЩИЕ МОДИФИЦИРОВАННОЕ ВЫСВОБОЖДЕНИЕ
专利权人:
ИПСЕН ФАРМА С.А.С. (FR)
发明人:
БАРОННЕ Мари-Мадлен (FR),РИШАР Жоэль (FR),МОНДОЛИ Натали (FR),НУРРИССОН Дидье (FR)
申请号:
RU2014153760
公开号:
RU2014153760A
申请日:
2013.06.06
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. An aqueous pharmaceutical composition comprising: - a peptide as an active ingredient and- one or more water-soluble or water-dispersible gelling agents, wherein the peptide ligand is selected from one or more melanocortin receptors (MC-R), or it is a pharmaceutically acceptable salt igeleobrazuyuschee agent is present in a concentration ranging from 10 to 50 wt.% relative to the total weight kompozitsii.2. Composition according to Claim. 1, wherein the peptide is a ligand of the MC4 melanocortin retseptora.3. Composition according to Claim. 1, wherein the peptide is Ac-Arg-c (Cys-D-Ala-His-D-Phe-Arg-Trp-Cys) -NHili pharmaceutically acceptable sol.4. A composition according to any one of claims. 1-3, wherein the peptide is in the form soli.5. A composition according to any one of claims. 1-3, wherein the pharmaceutically acceptable salt of the peptide is acetate or heptanoate, and preferably atsetat.6. A composition according to any one of claims. 1-3, wherein the peptide or its salt is present at a concentration ranging from 0.1 to 25 wt.%, Preferably from 0.1 to 10 wt.% Relative to the total weight kompozitsii.7. A composition according to any one of claims. 1-3, wherein the gelling agent is selected from polyethers and poliolov.8. A composition according to any one of claims. 1-3, wherein the gelling agent is present in a concentration ranging from 15 to 40 wt.% Relative to the total weight kompozitsii.9. A composition according to claim. 7, in which the polyether is selected from polyethylene glycols and preferably PEG 400.10. A composition according to claim. 9, wherein the polyether is PEG 400 present in a concentration ranging from 15 to 40 wt.%, And preferably from 20 to 35 wt.% Relative to the total weight kompozitsii.11. A composition according to claim. 7, in which the polyol is glitserin.12. A composition according to claim. 11 wherein the polyol is glycerol,1. Водная фармацевтическая композиция, содержащая:- пептид в качестве активного ингредиента и-
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