Liansheng Li,Jun Feng,Tao Wu,Yuan Liu,Yi Wang,Pingda Ren,Yi Liu
申请号：
US15989031
公开号：
US10736897B2
申请日:
2018.05.24
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I):or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein R1, R2a, R2b, R2c, R3a, R3b, R4a, R4b, L1, L2, E, X, Y, Z, m1 and m2 are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.
