Liansheng Li,Jun Feng,Yuan Liu,Tao Wu,Pingda Ren,Yi Liu
申请号：
US16480211
公开号：
US20190367489A1
申请日:
2018.01.24
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): (I) or a pharmaceutically acceptable salt, isotopic form, stereoisomer or prodrug thereof, wherein A, B, X, R1, R2a, R2b, R2c, L, L1 and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.
