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FUSED HETERO-HETERO BICYCLIC COMPOUNDS AND METHODS OF USE THEREOF
专利权人:
Araxes Pharma LLC
发明人:
Liansheng Li,Jun Feng,Yuan Liu,Pingda Ren,Yi Liu
申请号:
US16480874
公开号:
US20190345158A1
申请日:
2018.01.25
申请国别(地区):
US
年份:
2019
代理人:
摘要:
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I), or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, wherein A, W, X, Y, Z, and are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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