Compounds, particularly compounds having activity as modulators of cadherin-mediated cell adhesion having the following structure:or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof,wherein R1, R2, R3, R4, R5, R6, A, X, Y, Z, m and n are as defined herein. Methods associated with preparation and use of the same, as well as pharmaceutical compositions containing the same, are also disclosed.
