Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy) phenylmethyl)carbamide and its tartrate salt and crystalline forms
Carl-Magnus A. Andersson;Fritz Blatter;Mikkel Boas Thygesen;Nathalie Schlienger;Jörg Berghausen;Bo-Ragnar Tolf
发明人:
Mikkel Boas Thygesen,Nathalie Schlienger,Bo-Ragnar Tolf,Carl-Magnus A. Andersson,Fritz Blatter,Jörg Berghausen
申请号：
US13081427
公开号：
US08236960B2
申请日:
2011.04.06
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl) -N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2 -methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
