BOGLE DAVID EVERETT,ROSE PETER ROBERT,WILLIAMS GLENN ROBERT
申请号：
CZ20032916
公开号：
CZ304763B6
申请日:
2002.04.26
申请国别(地区):
CZ
年份:
2014
代理人:
摘要：
Tartrátové soli 5,8,14-triazatetracyklo[10.3.1.0.sup.2,11.n..0.sup.4,9.n.]hexadeka-2(11),3,5,7,9-pentaenu, jejich použití a farmaceutická kompozice s jejich obsahem. L-tartrátová sůl, včetně jejích dvou odlišných bezvodých polymorfů a hydrátového polymorfu. D-tartrátová sůl 5,8,14-triazatetracyklo[10.3.1.0.sup.2,11.n..0.sup.4,9.n.]hexadeka-2-(11),3,5,7,9-pentaenu a jeho polymorfů； D,L-tartrátové soli a její polymorfy a meso-tartrátové soli a její polymorfy.The present invention is directed to the tartrate salts of 5,8,14-triazatetracyclo [10.3.1.0e2,11.0e4,9]-hexadeca-2(11),3,5,7,9-pentaene of formula (1), and pharmaceutical compositions thereof. The present invention in particular is directed to the L-tartrate salt, and further to the various polymorphs of the L-tartrate salt, including two distinct anhydrous polymorphs and a hydrate polymorph. In addition, the present invention is also directed to the D-tartrate salt of 5,8,14-triazatetracyclo[10.3.1.0e2,11.0e4,9]-hexadeca-2(11),3,5,7,9-pentaene and the various polymorphs thereof； as well as the D,L-tartrate salt thereof and its polymorphs, and the meso-tartrate salt thereof and its polymorphs.
