Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms

• 收藏
• 分享

专利权人:

Acadia Pharmaceuticals Inc.

发明人:

Tolf, Bo-Ragnar,Blatter, Fritz,Thygesen, Mikkel,Berghausen, Jorg,Andersson, Carl-Magnus A.,Schlienger, Nathalie

申请号：

AU2005289444

公开号：

AU2005289444B2

申请日:

2005.09.26

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

Disclosed herein are methods for synthesizing N-(4-fluorobenzyl -N-(I-methylpiperidin­)4-yl)-N'-(442-methylpropyloxy)phenylmethyl)carbamide,Formula (I). Also disclosed herein is the hemi­tartrate salt of N-(4-fluorobenzyl)-N-(I-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)­phenylmethyl)carbamideand methods for obtaining the salt. Further disclosed are various crystallineforms of N-(4-fluorobenzyl)-N-(I-methylpiperidin-4-yl)-N'-(4-(2-metylpropyloxy)-phenymethyl)carbamideand its hemi-tartrate salt including various polymorphs and solvates.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/