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מלחי טרטראט של 14,8,5–טריאזאטטראציקלו [9,04.11,02.1.3.10] – הקסאדקא@–@@@@@@@@@@@@@–פנטא–אן@ותכשירי רוקחות המכילים אותם
专利权人:
PFIZER PRODUCTS INC.
发明人:
申请号:
IL15793303
公开号:
IL157933A
申请日:
2003.09.15
申请国别(地区):
IL
年份:
2013
代理人:
摘要:
The present invention is directed to the tartrate salts of 5,8,14-triazatetracyclo[10.3.1.0<;SUP>;2,11<;/SUP>;.0<;SUP>;4,9<;/SUP>;]-hexadeca-2(11),3,5,7,9-pentaene: and pharmaceutical compositions thereof. The present invention in particular is directed to the L-tartrate salt, and further to the various polymorphs of the L-tartrate salt, including two distinct anhydrous polymorphs (referred to herein as Forms A and B) and a hydrate polymorph (referred to herein as Form C). In addition, the present invention is also directed to the D-tartrate salt of 5,8,14-triazatetracyclo[10.3.1.0<;SUP>;2,11<;/SUP>;.0<;SUP>;4,9<;/SUP>;]-hexadeca-2(11),3,5,7,9-pentaene and the various polymorphs thereof; as well as the D,L-tartrate salt thereof and its polymorphs, and the meso-tartrate salt thereof and its polymorphs.
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