PURPOSE: A composition containing xanthohumol is provided to promote differentiation of osteoclast and to treat bone diseases.CONSTITUTION: A composition for preventing or treating osteoclast differentiation contains xanthohumol as an active ingredient. The composition contains xanthohumol and bone resorption inhibitor as an active ingredient. The bone absorption inhibitor is bisphosphonate, estrogen, calcitonin, vitamin D, calcium, fluoride, anabolic steroid or parathyroid hormone. A health functional food for preventing or treating osteoporosis contains xanthohumol as an active ingredient. The health functional food includes drink, meat, sausage, bread, candy, snack, noodle, ice cream, soup, isotonic drink, alcohol beverage, or vitamin complex.COPYRIGHT KIPO 2013본 발명은 잔토휴몰을 유효성분으로 하는 골다공증 예방 및 치료용 조성물에 관한 것으로 상기 잔토휴몰은 조골세포의 분화를 촉진하는 효과가 있어 골다공증을 비롯한 골질환의 치료에 효과적이다.