Lazar, Gregory Alan,Zhukovsky, Eugene Alexander,Pong, Erik Weiking,Bernett, Matthew J.,Karki, Sher Bahadur,Chu, Seung Yup,Desjarlais, John R.
申请号:
AU2008207898
公开号:
AU2008207898B2
申请日:
2008.01.23
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The present invention describes antibodies that target CD40, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcyR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.