Eugene Alexander Zhukovsky;Matthew J. Bernett;John R. Desjarlais;Seung Yup Chu;Gregory Alan Lazar;Erik WeiKing Pong;John O. Richards;Sher Bahadur Karki
发明人:
Matthew J. Bernett,Seung Yup Chu,John R. Desjarlais,Sher Bahadur Karki,Gregory Alan Lazar,Erik WeiKing Pong,John O. Richards,Eugene Alexander Zhukovsky
申请号：
US13221811
公开号：
US20120082664A1
申请日:
2011.08.30
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcγR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.
