The invention discloses methods for the generation of chimaeric human - non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies； compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.本發明揭示了用於產生嵌合入類-非人類抗體與嵌合抗體鏈的方法，依此製造的抗體與抗體鏈及其包括完全人源化抗體的衍生物；包含該抗體、抗體鏈與衍生物的組成物，還有適用於該方法的細胞、非人類哺乳動物與載體。
