The present invention relates to a polypeptide with endolysin activity comprising an amino acid sequence according to SEQ ID No. 1 and fragments or derivatives thereof, or fusion proteins derived thereof. Moreover, the present invention relates to nucleic acid molecules encoding said polypeptide or fusion protein, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid molecules or said vectors. In addition, the present invention relates to said polypeptide, fragment, derivative or fusion protein for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means, as cosmetic substance or as sanitizing agent. The present invention also relates to the use of said polypeptide, fragment, derivative or fusion protein for the treatment or prevention of Gram-negative bacterial contamination of foodstuff, of food processing equipment, of food processing plants, of surfaces coming into contact with foodstuff, of medical devices, of surfaces in hospitals and surgeries. Furthermore, the present invention relates to a pharmaceutical composition comprising said polypeptide, fragment, derivative or fusion protein.本發明有關包含序列識別號1所示的氨基酸序列的具有內溶素活性的多肽及其片段或衍生物,或其衍生的融合蛋白。此外,本發明有關編碼所述多肽或融合蛋白的核酸分子、包含所述核酸分子的載體和包含所述核酸分子或所述載體中任一的宿主細胞。另外,本發明有關作為藥物(特別是用於治療或預防革蘭氏陰性細菌感染)、作為診斷手段、作為化妝用物質或作為消毒劑使用的所述多肽、片段、衍生物或融合蛋白。本發明還有關所述多肽、片段、衍生物或融合蛋白用於處理或預防食品、食物加工設備、食物加工廠、與食品接觸的表面、醫學裝置、醫院和診所的表面的革蘭氏陰性細菌污染的用途。此外,本發明有關包含所述多肽、片段、衍生物或融合蛋白的藥物組合物。
