PAMPLONA, ANA,BERNARDES, GONÇALO, J. L.,MOTA, MARIA, M.,ROMÃO, CARLOS, C.
申请号:
EP12815454
公开号:
EP2734235A4
申请日:
2012.07.20
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute respiratory distress syndrome, which optionally may be associated with a malaria infection.