Ruthenium monoxide releasing molecules and uses thereof

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专利权人:

アルファーマ インコーポレイテッド

发明人:

パンプローナ，アナ,ベルナルデス，ゴンサロ，ジェイ．エル．,モタ，マリア，エム．,ロマン，カルロス，シー．,パンプローナ,アナ,ベルナルデス,ゴンサロ,ジェイ.エル.,モタ,マリア,エム.,ロマン,カルロス,シー.

申请号：

JP2014521837

公开号：

JP6134710B2

申请日:

2012.07.20

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof； wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute respiratory distress syndrome, which optionally may be associated with a malaria infection.

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中国工程科技知识中心

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